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Reduction in Resistance Training Volume and Neuromuscular Adaptations in Older Adults

NCT07046130 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2025-07-01

No results posted yet for this study

Summary

The goal of this clinical trial is to evaluate how reducing resistance training volume affects neuromuscular adaptations in older adults aged 60 to 70 years. The main questions it aims to answer are:

Can strength and muscle adaptations be maintained with lower training volume?

Does reducing training volume influence muscle power and hypertrophy in older adults?

Researchers will compare two groups:

A group that reduces training volume in one or both legs

A group that maintains the same training volume in both legs to see if reducing volume leads to different neuromuscular outcomes.

Participants will:

Complete an initial 10-week strength training program (2x/week) using unilateral leg press and knee extension machines, performing 3 sets per exercise

Undergo tests for muscle strength (1-RM), muscle thickness (ultrasound), and power (isokinetic dynamometry) at weeks 0, 5, and 10

After 10 weeks, be randomly assigned to:

A reduced-volume group: one leg does 2 sets and the other 1 set per exercise

Or a control group: both legs continue doing 3 sets

Continue training for another 10 weeks under the assigned protocol

Repeat strength, muscle thickness, and power assessments at weeks 5 and 10 of phase 2

Attend a dietary intake interview with a registered dietitian

This study will help determine the minimum effective training volume needed to maintain strength and muscle health in older adults, potentially improving long-term adherence to exercise programs.

Conditions

  • Sarcopenia in Elderly
  • Dynapenia

Interventions

BEHAVIORAL

Resistance Training

The mininum resistance training volume (12 sets/week) will be applied.

Sponsors & Collaborators

  • University of Sao Paulo

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-05-29
Primary Completion
2025-12-18
Completion
2026-12-18

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07046130 on ClinicalTrials.gov