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The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty

NCT06489626 · Status: WITHDRAWN · Phase: PHASE4 · Type: INTERVENTIONAL

Last updated 2026-02-05

No results posted yet for this study

Summary

Pain control and early range of motion following total knee arthroplasty are essential for patient satisfaction. Intraoperative steroids (dexamethasone) have been shown to have a significant effect in controlling acute pain following total knee arthroplasty. This study aims to evaluate the effect of a post-operative steroid (methylprednisolone) taper in improving functional and patient-reported outcomes following total knee arthroplasty. A taper means taking a high dose of a medication followed by taking lower doses and each following day until the medication is stopped.

Conditions

Interventions

DRUG

Methylprednisolone 4 milligram Tab

6-day 4 milligram methylprednisolone oral taper

DRUG

Dexamethasone injection

4 milligram intravenous dexamethasone will be administered intraoperatively

Sponsors & Collaborators

  • F. Johannes Plate

    lead OTHER

Principal Investigators

  • Johannes F Plate · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-11-01
Primary Completion
2027-10-01
Completion
2027-12-01
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06489626 on ClinicalTrials.gov