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Efficacy of Methylprednisolone for Pain Control After ACL Repair

NCT07158476 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2025-10-24

No results posted yet for this study

Summary

Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study is to investigate the impact of adding a methylprednisolone taper to the pain regimen after ACL repair surgery to determine if this results in decreased postoperative pain and opioid use without increasing complications.

Conditions

  • ACL Surgery
  • Pain Management

Interventions

DRUG

Meloxicam 15 mg

PO once/day for 1 week

DRUG

Medrol 4 MG Oral Tablet Includes Medrol Dosepak

PO 6 day taper

DRUG

Gabapentin 300 mg

PO every 8 hours for 1 week

DRUG

Hydrocodone 5Mg/Acetaminophen 325Mg Tab

PO 1-2 tabs every 4 hours as needed (total of 28 pills)

DRUG

Ketorolac 10 Mg Oral Tablet

PO every 6 hours for 5 days

Sponsors & Collaborators

  • St. Louis University

    lead OTHER

Principal Investigators

  • Scott Kaar, MD · St. Louis University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
13 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-21
Primary Completion
2030-09-30
Completion
2031-09-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07158476 on ClinicalTrials.gov