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Mechanisms for Atrial Fibrillation in Obstructive Sleep Apnea

NCT06465134 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2024-06-18

No results posted yet for this study

Summary

Atrial fibrillation (AF) is the most common rhythm disorder and involves an increased risk of cardiovascular disease and death, impaired quality of life and a high proportion of healthcare consumption. An important risk factor is obstructive sleep apnea (OSA). However, it is not fully understood why OSA induces AF. It may be due to a proinflammatory state, sympathetic activation and acute changes in blood pressure during apnéas, but few studies are performed. Hypertension with its coherent arterial stiffness is related to all these factors, is common in OSA, and is the most common cause of AF. The cause of AF in hypertensive subjects is believed due to a pressure overloaded left heart, with dilation and fibrosis of the left atrium, promoting the development of AF. Hypertension and arterial stiffness can thus be important triggering factors for AF in OSA.

In this project, teh investigators investigate the occurrence of OSA in AF patients. Furthermore, underlying mechanisms for the development and recurrence of AF after intervention in OSA patients are investigated.

300 patients scheduled for AF ablation or cardioversion are invited and examined with sleep registration, 24h blood pressure, aortic stiffness measurement, test of autonomic function, echocardiography, ECG and labs. The patients are followed at months 3, 6 and 12 with 7 days ECG for recurrence. The aim is to give insights into the need for screening for OSA in patients with AF. The study also aim at enabling preventive treatment through better understanding of underlying treatable mechanisms. The results are believed to lead to fewer new AFs, as well as fewer AF recurrences in patients with OSA.

Conditions

Interventions

OTHER

No intervention

There is no intervention

Sponsors & Collaborators

  • Istituto Auxologico Italiano

    collaborator OTHER

  • University of Trieste

    collaborator OTHER

  • Danderyd Hospital

    lead OTHER

Principal Investigators

  • Kristina Lundwall, MD PhD · KAROLINSKA INSTITUTE, DANDERYD HOSPITAL

  • Gianfranco Parati, Professor · Istituto Auxologico Italiano

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-11-01
Primary Completion
2025-05-31
Completion
2026-05-31

Countries

  • Italy
  • Sweden

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06465134 on ClinicalTrials.gov