Eating disorders are serious mental illnesses characterized by severe disturbances in eating behavior and related cognition about body weight and shape. Common forms include binge eating disorder, bulimia nervosa, and anorexia nervosa. These disorders can lead to substantial impairment and can be life-threatening.
A Cochrane review found intermittent fasting did not beat standard diet advice for weight loss. A separate trial found it matched calorie restriction but felt less restrictive. Experts advise a case-by-case approach given limited evidence.
New studies link GLP-1 drugs to eating disorders, erectile dysfunction and relationship changes, while Deloitte reports the drugs' market boom has lifted pharma R&D returns but created a concentration risk.
Clinical trials show psychedelic substances like psilocybin, LSD and MDMA combined with therapy can effectively treat depression, anxiety and addiction. Several substances are in Phase III trials, with esketamine already approved for treatment-resistant depression. Research suggests these treatments may work with fewer doses than traditional medications.
A new Cochrane review of 22 randomized trials finds intermittent fasting produces little to no meaningful weight loss compared to traditional dietary advice or no intervention in overweight or obese adults.
Compass Pathways reports positive Phase 3 results for synthetic psilocybin in treatment-resistant depression, while a Phase 2 trial demonstrates rapid antidepressant effects from single-dose DMT. Both studies show modest efficacy signals amid growing pharmaceutical interest in psychedelic compounds.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07750301 |
Development, Implementation, and Evaluation of the HADAS Program for the Prevention of Eating Disorders in Adolescent Female Athletes, Coaches, and Families. |
NOT_YET_RECRUITING | NA |
| NCT07740291 |
Tirzepatide Impact Assessment Study |
RECRUITING | NA |
| NCT07732829 |
FlexED: Full Threshold ED Substudy |
NOT_YET_RECRUITING | NA |
| NCT07698132 |
HALO-TRIAL: High, Medium And LOw Intensity Psychotherapy for Binge Eating Disorder |
RECRUITING | NA |
| NCT07685483 |
Dramatherapy for Psychological and Social Well-Being in Obesity and Bariatric Care |
RECRUITING | NA |
| NCT07678554 |
Overvaluation of Weight and Shape Intervention vs The Body Project |
NOT_YET_RECRUITING | NA |
| NCT07663916 |
Dog-Assisted Therapy in Adolescents Attending a Child and Adolescent Mental Health Day Hospital |
COMPLETED | NA |
| NCT07648108 |
Evaluation of a Day Hospital Program for Adolescents and Young Adults With Eating Disorders |
NOT_YET_RECRUITING | NA |
| NCT07632248 |
A Study Testing a Digital, Gamified Early Intervention for Eating Disorders ("FlexED") |
NOT_YET_RECRUITING | NA |
| NCT07610694 |
Eating Disorders in Patients With IBD |
COMPLETED |
