Eating disorders are serious mental illnesses characterized by severe disturbances in eating behavior and related cognition about body weight and shape. Common forms include binge eating disorder, bulimia nervosa, and anorexia nervosa. These disorders can lead to substantial impairment and can be life-threatening.
Clinical trials show psychedelic substances like psilocybin, LSD and MDMA combined with therapy can effectively treat depression, anxiety and addiction. Several substances are in Phase III trials, with esketamine already approved for treatment-resistant depression. Research suggests these treatments may work with fewer doses than traditional medications.
A new Cochrane review of 22 randomized trials finds intermittent fasting produces little to no meaningful weight loss compared to traditional dietary advice or no intervention in overweight or obese adults.
Compass Pathways reports positive Phase 3 results for synthetic psilocybin in treatment-resistant depression, while a Phase 2 trial demonstrates rapid antidepressant effects from single-dose DMT. Both studies show modest efficacy signals amid growing pharmaceutical interest in psychedelic compounds.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07600970 |
Using Bilateral Stimulation (A Pre-existing Trauma Technique) After Eating to Reduce Anxiety in People Recovering From Eating Disorders |
COMPLETED | NA |
| NCT07600671 |
Eating Disorder Dynamic Intervention |
NOT_YET_RECRUITING | NA |
| NCT07589621 |
Safety Behavior Fading Versus Progressive Muscle Relaxation for Appearance Concerns |
NOT_YET_RECRUITING | NA |
| NCT07565129 |
PrevED MR. Improving Emotion Dysregulation Through Mixed Reality Based Dialectical Behavioral Therapy in Adolescents and Young Adults at Risk of Developing Eating Disorders. |
NOT_YET_RECRUITING | NA |
| NCT07512479 |
Effectiveness of Hatha Yoga and From Feeling to Seeing the Body (FSB) in Female Adolescents and Young Adults With Eating Disorders. |
COMPLETED | NA |
| NCT07468188 |
Diabetes Body Project 2 |
RECRUITING | NA |
| NCT07466069 |
Lifestyle Intervention for Obesity and Eating Disorder Prevention in Transgender Adolescents |
RECRUITING | NA |
| NCT07458100 |
The STEP-MIED Trial: Digital Stepped-Care for Emotional Disorders |
RECRUITING | NA |
| NCT07452393 |
Psychological Factors and Self-Care Behaviors in Spanish Youth With Type 1 Diabetes: Age- and Sex-Based Comparisons and Associations |
COMPLETED | |
| NCT07434557 |
Disordered Eating and Recurrent Weight Gain After MBS |
ACTIVE_NOT_RECRUITING |
