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Metabolic Pathway Analysis in Intensive Care Unit Patients With Refeeding Syndrome

NCT06344546 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 218

Last updated 2025-04-02

No results posted yet for this study

Summary

The overall aim of the study is to improve understanding of refeeding syndrome (RFS) in patients admitted to the intensive care unit (ICU) using metabolomics. Patients are included as part of a prospective multicenter observational study on phosphate disorders in the ICU. Blood samples are collected day 1-7 of ICU stay. Samples from patients who develop refeeding hypophosphatemia and matched controls without hypophosphatemia are analysed for metabolomics and proteomics. Untargeted analyses will be performed to identify the affected metabolic pathways. The investigators will also perform AUROC analyses to identify potential biomarkers for early detection of RFS.

Conditions

  • Critical Illness
  • Refeeding Syndrome
  • Hypophosphatemia

Interventions

DIAGNOSTIC_TEST

Metabolomics

Analysis of the metabolome in plasma samples.

Sponsors & Collaborators

  • Foggia Hospital

    collaborator UNKNOWN

  • Faculty Hospital Kralovske Vinohrady

    collaborator OTHER_GOV

  • Karolinska University Hospital

    lead OTHER

Principal Investigators

  • Olav Rooyackers, PhD · Karolinska University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-04-01
Primary Completion
2024-06-02
Completion
2024-06-02

Countries

  • Czechia
  • Italy
  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06344546 on ClinicalTrials.gov