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The Effect of Aerosol Formed From Tobacco Heating Systems on the Microbiome of Supragingival Dental Biofilm

NCT06314100 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2024-03-15

No results posted yet for this study

Summary

Dental caries is a multifactorial disease primarily caused by supragingival dental biofilm. Its progression is influenced by many environmental factors, which include smoking. Tobacco heating systems (THS) are a novel tobacco product whose effect on the microbiome of the supragingival dental biofilm has not yet been investigated.

The aim of the proposed research is to determine and compare the composition of the microbiomes of the supragingival dental biofilm of THS smokers, cigarette smokers, and nonsmokers using the Next Generation Sequencing method and to assess and compare the risk of new caries lesion formation between the test groups using the Cariogram method.

The results of this research will provide insight into changes in the microbiome of the supragingival dental biofilm resulting from exposure to aerosols from tobacco combustion and tobacco heating.

Conditions

  • Dental Caries

Interventions

DEVICE

Tobacco heating systems

The study aims to explore the effect of tobacco heating system consumption on microbiome of the supragingival dental biofilm and the risk of developing caries lesions

BEHAVIORAL

cigarette smoking

The study aims to explore the effect of cigarette smoking on microbiome of the supragingival dental biofilm and the risk of developing caries lesions

BEHAVIORAL

non smoking

The non smoking group of subjects serve as control for the other two groups

Sponsors & Collaborators

  • Croatian Science Foundation

    collaborator OTHER_GOV

  • University of Rijeka

    lead OTHER

Principal Investigators

  • Elvis Božac, DMD · Faculty of dental medicine, University of Rijeka

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-10-01
Primary Completion
2023-10-25
Completion
2023-10-25
FDA Device
Yes

Countries

  • Croatia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06314100 on ClinicalTrials.gov