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A Clinical and Imaging Study to Evaluate a Novel Dentifrice

NCT02271815 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 194

Last updated 2022-09-15

No results posted yet for this study

Summary

There is a need for toothpastes that more effectively remove oral biofilm, inhibit biofilm re-formation and support periodontal health. This is particularly important for patients with long-term orthodontic fixtures or prosthodontic appliances, and also for debilitated, diabetic and immunocompromised patients. The objective of this study is to evaluate the effects of toothpastes on plaque presence and removal, gingival and periodontal health, dental hard tissue mineralization, erosion, abrasion, and microstructure as well as dry/sore mouth. In addition to clinical scoring and photographs, tooth and gum sensitivity, saliva volume, pH and buffering and enamel health may be evaluated using tooth samples worn on removable dental retainers. These samples will be examined outside of the mouth using advanced optical techniques such as Optical Coherence Tomography (OCT), Fluorescence, various forms of microscopy and spectroscopy.

Conditions

  • Gingivitis
  • Periodontitis
  • Dental Plaque

Interventions

OTHER

Oral Hygiene

Oral Hygiene

Sponsors & Collaborators

  • Livionex Inc.

    collaborator INDUSTRY

  • University of California, Irvine

    lead OTHER

Principal Investigators

  • Petra Wilder-Smith, DDS, DMD, PhD · Beckman Laser Institute, UCI

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-10-31
Primary Completion
2021-06-30
Completion
2021-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02271815 on ClinicalTrials.gov