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The Effect of Arginine on Biofilm Composition, Architecture and Metabolism

NCT06135792 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2024-12-27

No results posted yet for this study

Summary

Arginine is an adjunct to oral health care that has the potential to modulate the composition and activity of the microbial community of dental biofilms towards a health-related status without harmful effects for the resident oral microbiota. The aim of the study is to investigate the effects of arginine treatment compared to placebo on the composition, metabolism, and microarchitecture of biofilms grown in situ in the oral cavity of caries-active participants.

Conditions

  • Dental Caries
  • Dental Plaque
  • Microbial Colonization

Interventions

OTHER

Arginine

See arm description

OTHER

Placebo

See arm description

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Sebastian Schlafer · University of Aarhus

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-10-19
Primary Completion
2024-02-13
Completion
2024-02-13

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06135792 on ClinicalTrials.gov