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Diastolic Dysfunction in Septic Shock and Cardiomyopathy Genetic Variants

NCT05552521 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2024-08-09

No results posted yet for this study

Summary

Sepsis is a life-threatening infection with increasing incidence, and its spectrum of disease can involve cardiac dysfunction, which further adds to mortality. Although cardiac involvement in sepsis has been classically attributed to systolic dysfunction, diastolic dysfunction is increasingly diagnosed due to new echocardiographic techniques and the conceptual evolution of diastolic dysfunction. Combining systolic and diastolic dysfunction assessment could lead to a better diagnosis of septic cardiac dysfunction. Furthermore, earlier forms of septic cardiac dysfunction could be more promptly recognized by measuring novel and less used parameters of diastolic dysfunction. We hypothesize that left atrium (LA) strain and isovolumetric relaxation time (IVRT) derived intervals could be new and earlier predictors of diastolic dysfunction in septic patients with a potential impact on clinical presentation and prognosis and that rare genetic variation associated with inherited cardiomyopathies could underline the risk and severity of sepsis-related myocardial dysfunction with potential impact on diagnosis and prognosis.

Conditions

  • Diastolic Dysfunction
  • Septic Shock
  • Cardiomyopathies

Interventions

DIAGNOSTIC_TEST

Echocardiography

Echocardiography in 4 timepoints: 1st 24h + 7th-10th day; 28th-30th day; 6 months Whole exome sequencing at admission

Sponsors & Collaborators

  • Instituto de Medicina Molecular João Lobo Antunes

    collaborator OTHER

  • Hospital Garcia de Orta

    lead OTHER

Principal Investigators

  • Filipe A Gonzalez, MD, PhD st. · Hospital Garcia de Orta

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-20
Primary Completion
2024-02-26
Completion
2024-02-26

Countries

  • Portugal

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05552521 on ClinicalTrials.gov