Night Shift Work and Biomarkers of Obesity Risk in Hospital and Industry Workers

Summary

Shift work is a well-known risk factor for the development of overweight and obesity, which may lead to downstream effects such as increased risk of cardiometabolic diseases and cancer. However, the biological and behavioral mechanisms underlying the obesogenicity of night shift work are not well understood. Population-based mechanistic studies in real life shift workers are needed to address how night shift work impacts metabolic health.

The investigators aim to characterize the behavioural, environmental, and biological mechanisms and pathways for the association of night shift work and obesity across Europe.

The investigators will conduct a cross sectional study in 5 European countries (Austria, Denmark, Germany, Netherlands and Poland) and recruit 1000 rotating night shift workers and day workers (200/country) from the health sector and different industries. Night and day workers will be age-frequency (3 age groups), gender and (where possible) working tasks matched. Participants will complete online questionnaires and report their diet habits in a mobile app. Body composition, dietary behavior and sensory preferences will be tested. Biologic specimens (blood, urine, saliva, hair and feces) will be collected at the workplace on a day where participants are working on a day shift (or a day off). In a subsample (Austria and Netherlands) shift workers will provide biological samples (spot blood, urine and saliva) both on a day shift and on a night shift. Biomarkers including hormones, cellular immunity and inflammation, parameters linked to gut health and metabolism of fat and sugar, appetite, oxidative stress, metabolomics and microbiota will be measured. The investigators hypothesize that compared to day workers, night shift workers will experience disrupted levels of pre-obesity markers. Higher circadian disruption, sleep disruption and mistimed eating patterns workers will be associated with more disrupted biomarker profiles. Among rotating shift workers, night shift will be associated with acute disrupted melatonin production, metabolomic profiles and composition of oral microbiota compared to a day shift.

Conditions

• Obesity
• Shift-work Disorder
• Circadian Rhythm Disorders

Interventions

OTHER

No intervention

No intervention

Sponsors & Collaborators

• Medical University of Vienna

  collaborator OTHER

• FH Joanneum Gesellschaft mbH

  collaborator INDUSTRY

• Wageningen University and Research

  collaborator OTHER

• Wageningen University

  collaborator OTHER

• University of Bremen

  collaborator OTHER

• Verein zur Förderung des Technologietransfers an der Hochschule Bremerhaven e.V.

  collaborator UNKNOWN

• UNIVERSYTET MEDYCZNY W LODZI

  collaborator UNKNOWN

• Københavns Universitet

  collaborator OTHER

• Charite University, Berlin, Germany

  collaborator OTHER

• Erasmus Medical Center

  collaborator OTHER

• University of Vienna

  lead OTHER

Eligibility

Min Age

21 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-04-01

Primary Completion

2025-11-01

Completion

2028-05-31

Countries

• Austria

Study Locations