Effect of a Short Nap During the Night Shift of Healthcare Workers on Endothelial Function

Summary

Night shift work is well known to cause health disruption in short and long term. It has been reported that among healthcare workers, nurses slept less than 6 h/24h. Consequences of such short sleep duration has been associated to long term issues such as endothelial dysfunction associated with cardiovascular diseases, arterial hypertension and type 2 diabetes. Countermeasures such as nap at work has potential effects on reducing the prevalence of cardiovascular diseases. However, to our knowledge, no studies have objectively investigated the effects of napping on endothelial function in a longitudinal design. Therefore, this study aims to investigate the effect of a 30 minutes on-duty nap during night work for 12 weeks on caregivers endothelial dysfunction.

Conditions

• Healthy Volonteers

Interventions

BEHAVIORAL

On-duty Nap

For 12 weeks, an opportunity for a 30-minute nap during the night shift, between 1 a.m. and 4 a.m., in a quiet room with facilities for lying down.

BEHAVIORAL

Control condition (30-min rest)

For 12 weeks, an opportunity for a 30-minute rest during the night shift, between 1 a.m. and 4 a.m., in a quiet room without facilities for lying down or napping.

DEVICE

EndoPAT

The EndoPAT device® measures vascular reactivity after a 5-minute occlusion on one arm. This device measures changes in vascular tone induced by the endothelium at fingertip level using a pair of plethysmographic sensors. The measurement consists of performing a reference recording for 5 minutes on the 2 arms, then a test arm is chosen to perform an occlusion for 5 minutes while continuing the recording.

DEVICE

Popmeter®

The tool is connected to the caregiver's finger and toe via photodiode sensors. Its simple operation enables reproducible measurement of the propagation speed of the pulse wave in 14 seconds.

DEVICE

Panasonic EW3109

Diastolic and systolic blood pressure measured 3 times in succession using an automatic blood pressure monitor (Panasonic EW3109) in the sitting position on the left arm.

DEVICE

ECG Holter

The Holter takes an ECG during the subject's daily activities at home.

BIOLOGICAL

Fasting blood sample

15 ml blood sample (venous sampling) will be taken to measure inflammatory biomarkers (hsCRP, IL-6 TNF-α, IL-1β) and blood markers of endothelial function (NO, CRP, SOD, IL-18).

OTHER

Pichot fatigue scale

The Pichot fatigue scale is an 8-item questionnaire, with a score above 22 indicating excessive fatigue.

OTHER

French version of the Recovery Needs Scale (BRD)

BRD questionnaire consists of 11 items coded 0 or 1. A score is calculated for each participant, multiplied by 10 to give a score ranging from 0 to 100. The greater the need for recovery, the higher the score.

OTHER

The Short-Form 36 (SF-36)

The SF-36 questionnaire is used to assess quality of life. It comprises 8 sub-scores ranging from 0 (minimum quality of life) to 100 (maximum well-being).

OTHER

Pittsburgh Sleep Quality Index (PSQI)

24-question sleep quality assessment scale, a score \> 5 indicates poor sleep quality

OTHER

Epworth questionnaire

8-question sleepiness assessment scale, a score above 10 indicates excessive sleepiness

OTHER

The Karolinska Sleepiness Scale

The Karolinska Sleepiness Scale measures daytime sleepiness on a 9-point scale, based on 5 states and 4 intermediate states that are not verbally indicated.

DEVICE

Actimeter

An actimeter will be worn on the non-dominant wrist, uninterrupted day and night, for 7 consecutive days.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne

  lead OTHER

Principal Investigators

• Frédéric ROCHE, MD PhD · Centre Hospitalier Universitaire de Saint Etienne

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-02-19

Primary Completion

2025-09-26

Completion

2025-12-22

Countries

• France

Study Locations