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Selected Immunological Indicators and Microbiota in Patients With Premature Birth and Preeclampsia

NCT06281262 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2024-03-01

No results posted yet for this study

Summary

The goal is to demonstrate the relationship of the circulating pool of T-regulatory lymphocytes in the mother's peripheral blood with populations in the placentas and to compare with controls, what is the difference in the expression of individual regulatory molecules of T-regulatory lymphocytes according to new paradigms. The proportional and functional characteristics of T-regulatory lymphocytes will be correlated with the composition of the intestinal and vaginal microbiota.

Conditions

Interventions

DIAGNOSTIC_TEST

Peripheral blood collection

The phenotypic characteristics of leukocytes will be compared between the groups to identify immunological markers of women at risk of preterm delivery. Samples from the controls will be taken to define a baseline for the measured leukocyte populations.

DIAGNOSTIC_TEST

Swab sample collection

Oral, vaginal and rectal swabs will be collected and stored for analysis of microbiota at the time of inclusion. At birth, oral, vaginal and rectal swabs and part of the placenta (placental tissue) will be collected for further analysis.

Sponsors & Collaborators

  • Charles University, Czech Republic

    collaborator OTHER

  • Institute of Hematology and Blood Transfusion, Czech Republic

    collaborator OTHER

  • General University Hospital, Prague

    lead OTHER

Principal Investigators

  • Zdeněk Laštůvka, MD, PhD · General University Hospital, Prague

Eligibility

Min Age
19 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-06-30
Primary Completion
2025-03-30
Completion
2025-03-30

Countries

  • Czechia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06281262 on ClinicalTrials.gov