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Polymorphism of ApoE in Alzheimer's Disease: Genetic Study in Castile and Leon (Spain)

NCT06275243 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 511

Last updated 2024-05-08

No results posted yet for this study

Summary

The general objective of this randomized and longitudinal clinical study was to estimate the frequencies of ApoE variants both in the user population of the "Messengers of Peace" Residences and the "Associations of Relatives of Alzheimer's Patients" in Castile y Leon, since, due to its geographical location at the crossroads, it has received multiple genetic contributions from both northern Europe, the Mediterranean area and northern Africa.

The main questions it aims to answer are:

* What are the allelic frequencies of ApoE variants in the population of individuals with Alzheimer's disease in Castile and Leon?
* Is there a correlation between the ApoE4 variant and the lipid profile in the blood of individuals with Alzheimer's disease in this region?

Conditions

  • Alzheimer Disease

Interventions

DIAGNOSTIC_TEST

Kit Buccal swab collection & stabilization de Canvax®

Assessment of ApoE variant in saliva samples as a potential biomarker for Alzheimer's disease.

OTHER

Cholesterol levels according to ApoE Genotype

Enhancing the quality of life of study participants by investigating cholesterol levels based on their ApoE genotype.

OTHER

Assessing cardiovascular risk factors in all participants

Through individual interviews, record cardiovascular factors and assess their correlation with Alzheimer's disease.

Sponsors & Collaborators

  • Consejo General de Colegios Oficiales de Enfermería España

    collaborator UNKNOWN

  • Universidad de León

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-07-06
Primary Completion
2023-03-13
Completion
2024-03-22

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06275243 on ClinicalTrials.gov