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Apolipoprotein E (ApoE) and Metabolism

NCT03109561 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2020-07-23

No results posted yet for this study

Summary

Impaired metabolism and the gene apolipoprotein E (ApoE) are independent risk factors for cognitive impairment and dementia. In humans, there are three major versions of apoE (E): E2, E3, and E4. Some studies suggest that the different versions of apoE have varying effects on whole body and brain metabolism. The goal of this project is to better understand the relationship between apoE and metabolism. This will help investigators identify new targets for the prevention and treatment of cognitive decline and dementia.

Conditions

  • Cognitive Function
  • Healthy

Interventions

OTHER

Resting State Indirect Calorimetry

The investigator will measure the amount of oxygen participants breathe in and the amount of carbon dioxide they breathe out using a portable unit. Participants will be asked wearing a loose-fitting face mask that measures oxygen intake and carbon dioxide output.

GENETIC

ApoE

The investigator will conduct a genetic test on DNA isolated from from the participants blood. Participants will be asked to provide about 2 tablespoons.

DIAGNOSTIC_TEST

Metabolism

To more accurately measure the amount of carbohydrates, fats and proteins that the participants bodies metabolize, participants will be asked to provide two urine samples (one at the beginning, and one at the end, of the study). The total amount of urine to be collected is approximately 4 teaspoons.

OTHER

Cognitive Challenge

Participants will be asked to follow simple instructions that are displayed on computer screen.

Sponsors & Collaborators

  • Lance Johnson

    lead OTHER

Principal Investigators

  • Lance Johnson1, PhD · University of Kentucky

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-04-24
Primary Completion
2020-01-30
Completion
2020-01-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03109561 on ClinicalTrials.gov