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Energetics and Glutamate in Schizophrenia

NCT06236048 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 75

Last updated 2025-09-05

No results posted yet for this study

Summary

The goal of this case-control study is to compare brain glutamate, glucose utilisation, lactate production and brain activity in healthy volunteers and people with a diagnosis of schizophrenia.

It investigates the following main questions:

Whether, compared to healthy volunteers, participants with schizophrenia show:

1. reduction in brain glucose utilisation
2. increased brain lactate
3. greater variability in brain glutamate

Participants will be asked to have a screening visit, a MRI brain scan and a PET-MRI brain scan.

Conditions

Interventions

PROCEDURE

MRI scan

7 Tesla MRI scan

PROCEDURE

PET-MR scan

18F-fluorodeoxyglucose PET-MR scan

Sponsors & Collaborators

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-03-04
Primary Completion
2027-12-31
Completion
2028-12-01

Countries

  • United Kingdom

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06236048 on ClinicalTrials.gov