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Brain Activation Patterns in Schizophrenia After Computerized Cognitive Skills Training

NCT00431223 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 11

Last updated 2020-10-06

No results posted yet for this study

Summary

This project is a novel exploratory research project to investigate changes in activation patterns of the dorsolateral prefrontal cortex (DLPFC) in inpatients with schizophrenia who received a 12-week computerized cognitive remediation (CRT) program. The hypothesis is that patients receiving CRT will show greater increase in activation patterns in the brain as compared to controls, and the degree of brain activation will correlate with improvements in working memory.

Conditions

Interventions

BEHAVIORAL

Cognitive remediation therapy

36 sessions of computerized cognitive skills training over a 12 week duration. 7 patients were assigned to cognitive remediation therapy or CRT Group.

Sponsors & Collaborators

  • Nathan Kline Institute for Psychiatric Research

    collaborator OTHER

  • Manhattan Psychiatric Center

    lead OTHER

Principal Investigators

  • Saurabh Kaushik, MD · Manhattan Psychaitric Center

  • Jean-Pierre Lindenmayer, MD · Manhattan Psychiatric Center

  • Susan McGurk, PhD · Dartmouth College, Hanover

  • Craig A. Branch, PhD · Center for Advanced Brain Imaging, NKI

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-09-30
Primary Completion
2008-09-30
Completion
2008-09-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00431223 on ClinicalTrials.gov