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The Effect of Plasma Osmolality on Brain Glutamate

NCT00611741 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2016-02-09

No results posted yet for this study

Summary

This study is designed to test the hypothesis that plasma osmolality is linked with cortical glutamate concentrations in the brain. It also investigates whether the glutamate response in schizophrenia is enhanced compared to healthy controls.

Conditions

Interventions

DRUG

furosemide, Na supplements

furosemide 20 mg, Na supplements 8g in divided doses/day for 5 days

Sponsors & Collaborators

  • Yale University

    lead OTHER

Principal Investigators

  • Handan Gunduz-Bruce, M.D. · Yale University

Study Design

Allocation
NA
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
21 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-03-31
Primary Completion
2011-03-31
Completion
2012-03-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00611741 on ClinicalTrials.gov