MedTrace Logo

Psychosis-Associated Neuroinflammation in Schizophrenia

NCT02009826 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 106

Last updated 2017-08-31

No results posted yet for this study

Summary

Previous research has suggested central nervous system inflammatory activity to be critically involved in disease development and progression in schizophrenia, with a complex interplay of inflammatory mechanisms leading to the development of brain abnormalities and medical symptoms related to schizophrenia. However, the mutual interactions of different inflammatory pathways and their relation to disease course have not been sufficiently studied. This study therefore aims to explore the interaction of neuroinflammatory mechanisms in patients with schizophrenia and to assess whether the inflammatory activity in schizophrenia is state-dependent and occurs mainly during psychotic episodes.

Conditions

Interventions

RADIATION

[18F]-PBR111 Positron Emission Tomography (PET)

\[18F\]-PBR111 radioligand to assess binding to TSPO

BEHAVIORAL

Cognitive and psychomotor tasks

Cognitive and psychomotor tasks on digitizing tablet

BIOLOGICAL

Blood sampling

Blood sampling for peripheral inflammatory and neurotoxicity markers

Sponsors & Collaborators

  • Agentschap voor Innovatie door Wetenschap en Technologie

    collaborator OTHER

  • Janssen Research & Development, LLC

    collaborator INDUSTRY

  • Universiteit Antwerpen

    lead OTHER

Principal Investigators

  • Bernard Sabbe, MD PhD · Universiteit Antwerpen

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-11-30
Primary Completion
2017-02-28
Completion
2017-02-28

Countries

  • Belgium

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02009826 on ClinicalTrials.gov