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Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients

NCT06189924 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2026-03-23

No results posted yet for this study

Summary

Mechanically ventilated intensive care patients will be sampled for a small amount of exhaled breath condensate from the ventilator circuit and for venous blood.

Proteomic analysis of the exhaled breath condensate will be performed using mass spectrometry and in the blood sample, corresponding changes in the DNA, RNA, proteins, and metabolites will be studied. Resulting profiles will be correlated with routinely monitored parameters in order to identify patterns corresponding to various pathologies in order to enable their early detection.

Conditions

  • Acute Respiratory Failure
  • Critical Illness

Interventions

DIAGNOSTIC_TEST

Proteomic analysis of exhaled breath condensate

Mechanically ventilated intensive care patients will be sampled for exhaled breath condensate from the ventilator circuit.

Sponsors & Collaborators

  • The Institute of Molecular and Translational Medicine, Czech Republic

    lead OTHER

Principal Investigators

  • Emil Berta, MD PhD · IMTM, Palacky University in Olomouc, Faculty of Medicine and Dentistry

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-01
Primary Completion
2028-12-31
Completion
2029-12-31

Countries

  • Czechia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06189924 on ClinicalTrials.gov