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The Effect of High Frequency Oscillation on Biological Markers of Lung Injury

NCT01581255 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 2

Last updated 2012-09-12

No results posted yet for this study

Summary

Mechanical ventilation, although life-saving, damages the lungs through what is known as ventilator-induced lung injury. High frequency oscillation ventilation has been proposed as a ventilation method that may be less injurious to the lungs than conventional mechanical ventilation and may lead to better patient outcomes. To evaluate this hypothesis, the OSCILLATE trial is comparing outcomes in patients with the acute respiratory distress syndrome randomized to high frequency oscillation ventilation vs conventional lung protective ventilation. The present study is a substudy of the OSCILLATE trial looking at biomarkers of ventilator-induced lung injury in blood samples drawn from patients enrolled in OSCILLATE. The objective is to look for biochemical evidence of decreased ventilator-induced lung injury in patients treated with high frequency oscillation ventilation relative to conventional ventilation.

Conditions

  • Acute Respiratory Distress Syndrome

Sponsors & Collaborators

  • Canadian Intensive Care Foundation

    collaborator OTHER

  • Canadian Critical Care Trials Group

    lead OTHER

Principal Investigators

  • Alexandra Binnie, MD, DPhil · University of Toronto

  • Claudia dos Santos, MD, PhD · University of Toronto

  • Niall Ferguson, MD, MSc · University of Toronto

Eligibility

Min Age
16 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-02-29
Primary Completion
2012-08-31
Completion
2012-08-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01581255 on ClinicalTrials.gov