Effects of Probiotics on Metabolic Syndrome ,Intestinal Microflora and SCFA.

Summary

The improvement effects of GLAC biotech probiotics contains 5 specialized strains on the biochemical analysis and gut microbiota will be verified in the clinical trial through cooperation with the ADPRC. Through this project, the difference and improvement before and after the GLAC biotech probiotics taking will be clinically validated fromseveral aspects, including blood biochemical values, NGS gut microbiota analysis, GAIS and SCFAs levels. Therefore, by this industry- academic cooperation project, the investigators can explore the improvement of human gut microbiota by GLAC biotech probiotics, to understand the essence of clinical benefit, and the investigators expect the accomplishments of this project can help the consumers understand the added value and excellence of the GLAC products, and thus enhance consumer confidence and expand product markets.

Conditions

• Metabolic Syndrome

Interventions

DIETARY_SUPPLEMENT

Probiotics 1

Subjects take probiotics capsule(Lactobacillus fermentum,TSF331) three times a day before meal.

DIETARY_SUPPLEMENT

Probiotics 2

Subjects take probiotics capsule(Lactobacillus reuteri,TSR332) three times a day before meal.

DIETARY_SUPPLEMENT

Probiotics 3

Subjects take probiotics capsule(Lactobacillus plantarum,TSP05) three times a day before meal.

DIETARY_SUPPLEMENT

Probiotics 4

Subjects take probiotics capsule(Lactobacillus fermentum,TSF331+Lactobacillus reuteri,TSR332+Lactobacillus plantarum,TSP05) three times a day before meal.

DIETARY_SUPPLEMENT

Probiotics 5

Subjects take probiotics capsule(Lactobacillus fermentum,TSF331+Lactobacillus reuteri,TSR332+Lactobacillus plantarum,TSP05+Postbiotics PE0401) three times a day before meal.

DIETARY_SUPPLEMENT

Placebo 1

Subjects take capsule three times a day before meal.

DIETARY_SUPPLEMENT

Probiotics 6

After 1 month wash out, subjects take probiotics capsule(Bifidobacterium animalis subsp. lactis,CP-9) three times a day before meal.

DIETARY_SUPPLEMENT

Probiotics 7

After 1 month wash out, subjects take probiotics capsule(Lactobacillus rhamnosus, bv-77+Bifidobacterium animalis subsp. lactis,CP-9) three times a day before meal.

DIETARY_SUPPLEMENT

Placebo 2

After 1 month wash out, subjects take capsule three times a day before meal.

Sponsors & Collaborators

• Glac Biotech Co., Ltd

  lead INDUSTRY

Principal Investigators

• Hsieh-Hsun Ho, Ph. D. · Study Principal Investigator

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

FACTORIAL

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-08-01

Primary Completion

2022-09-30

Completion

2023-03-31

Countries

• Taiwan

Study Locations