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The Effect of Probiotics on Obesity. Metabolic Endotoxemia and Inflammation

NCT03883685 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2021-06-08

No results posted yet for this study

Summary

In spite of the growing evidence for the beneficial effects of probiotics, their anti-obesity effects are not well examined. No previous studies were conducted in this research area in the UAE. Hence, the aims of this study are to 1) Investigate the link between metabolic derangements associated with obesity and levels of LPS and LBP; 2) Study the relatedness of low grade inflammation with the ME; 3) Investigate the food intake assessment; and 4) Investigate the effectiveness of probiotics supplement on the obesity, ME and inflammation.

This project will have two phases: 1) a cross-sectional, in which 250 adults will be recruited for the collection of anthropometric measures, food intake, and fasting blood samples to measure serum LPS, LBP, Lipid profile, IR, insulin-like growth factor, hs-CRP, IL-6, and glucose. 2) Intervention phase, in which 50 overweight subjects will be randomly assigned to either receive a daily probiotic (25 subjects) or a placebo capsule (25 subjects) during the intervention period.

Conditions

  • Metabolic Syndrome

Interventions

DIETARY_SUPPLEMENT

Probiotane

probiotics capsules of blended strains including Lactobacillus acidophilus, L. casei and L. rhamnosus

DIETARY_SUPPLEMENT

Placebo

Placebo

Sponsors & Collaborators

  • Universiti Sains Malaysia

    collaborator OTHER

  • University of Sharjah

    lead OTHER

Principal Investigators

  • Dr. Raed AbuOdeh, PhD · University of Sharjah

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-01-01
Primary Completion
2019-05-19
Completion
2019-09-01

Countries

  • United Arab Emirates

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03883685 on ClinicalTrials.gov