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EPO for Postop Delirium in Elderly Patients

NCT06178835 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 76

Last updated 2023-12-21

No results posted yet for this study

Summary

Postoperative delirium is a common complication after surgery. The underlying pathophysiology of this complication is unclear, however neuroinflammation and oxidative stress secondary to surgery had shown to be the cause of postoperative cognitive dysfunction and delirium. Erythropoietin represents non-erythropoietic effects of anti-inflammatory properties. The aims of this study were to determine the role of erythropoietin toward the development of postoperative delirium, in terms of changes in inflammatory reaction by affecting the innate immunity in elderly patients undergoing total joint arthroplasty surgery.

Conditions

  • Postoperative Delirium

Interventions

DRUG

Erythropoietin

500 IU/kg of erythropoietin is given 3 times for each patient: the day before surgery, start of surgery and on postoperative day 1.

DRUG

normal saline

The same amount of normal saline is given 3 times for each patient: the day before surgery, start of surgery and on postoperative day 1.

Sponsors & Collaborators

  • Yonsei University

    lead OTHER

Principal Investigators

  • Bon-Nyeo Koo · Department of Anesthesiology and Pain medicine, Severance Hospital, Seoul, South Korea

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-09-12
Primary Completion
2019-07-28
Completion
2019-08-28

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06178835 on ClinicalTrials.gov