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Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery

NCT06653465 · Status: NOT_YET_RECRUITING · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 1930

Last updated 2025-04-04

No results posted yet for this study

Summary

Investigators propose this multi-center randomised controlled study to test the preventive effect of intravenouse acetaminophen in delirium over 5 postoperative days among older patients recovering from major non-cardiac surgery.

Conditions

  • Delirium in Old Age

Interventions

DRUG

Acetaminophen

Acetaminophen, which has similarly effects with NSAIDs in terms of inhibition of cyclooxygenase COX1, COX2 and COX3, is widely used as adjuvant for perioperative multimodal analgesia.

DRUG

Saline

Saline, a kind of crystalloid widely used in clinical treatment.

Sponsors & Collaborators

  • RenJi Hospital

    lead OTHER

Principal Investigators

  • LIQUN YANG, MD · Anesthesiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine Shanghai, China

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-30
Primary Completion
2027-06-30
Completion
2027-07-31

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06653465 on ClinicalTrials.gov