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Postoperative Delirium at Heidelberg's Intensive Care Unit -New Diagnostic Markers

NCT00463333 · Status: COMPLETED · Type: OBSERVATIONAL

Last updated 2007-04-20

No results posted yet for this study

Summary

Summary:

Postoperative delirium is a highly prevalent disease (10-30% prevalence) after surgery in intensive care unit, however, it is often misdiagnosed and mistreated. The aim of the present project is to investigate risk factors for postoperative delirium in more detail, to evaluate respective cognitive test systems and to measure EEG activity parallel to patients' serum anticholinergic activity. The pathophysiology of delirium is unknown up to now: a possible dysbalance between cerebral acetylcholine and dopamine concentrations is a likely hypothesis. Therefore, the measurement of peripheral serum anticholinergic activity could be a new prognostic factor for evaluation of delirium. Because delirium is also associated with higher postoperative mortality and morbidity, with delayed functional recovery, and postoperative delirium makes patient management much more difficult, increases costs, and, above all, causes severe discomfort to the patient new interdisciplinary diagnostic strategies are necessary to resolve this problem.

Conditions

  • Postoperative Delirium

Sponsors & Collaborators

  • Else Kröner Fresenius Foundation

    collaborator OTHER

  • Heidelberg University

    lead OTHER

Principal Investigators

  • Markus A Weigand, PhD, MD · Medical Faculty, Clinic of Anesthesiology, University of Heidelberg

  • Konstanze Plaschke, Prof. · Clinic of Anesthesiology

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-05-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00463333 on ClinicalTrials.gov