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Establishing a New Ultrasound Technique to Improve Assessment of Chronic Kidney Disease.

NCT06159439 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2023-12-06

No results posted yet for this study

Summary

Blood flow to the kidneys is important in the development of kidney diseases. Currently we do not have ways of measuring and monitoring kidney blood flow for patients in real-time. This is a major barrier to investigation and management of acute kidney injury (AKI) and chronic kidney disease (CKD).

Kidney blood flow can be reliably measured using a specialised type of MRI scan, but this is expensive and difficult to do in people who are unwell. Contrast-enhanced ultrasound (CEUS) is a new technique, which uses a contrast containing microbubbles to measure blood flow. The benefits of this method are that it is relatively inexpensive, the contrast agents are not kidney-damaging and it can be done at the bedside.

We want to compare contrast enhanced ultrasound against the current best-measure of kidney blood flow, to see if it is giving accurate information about kidney blood flow. We will do this by doing both MRI and contrast enhanced ultrasound scans in people with chronic kidney disease and comparing the results.

Conditions

  • Chronic Kidney Diseases

Interventions

DIAGNOSTIC_TEST

Contrast enhanced ultrasound scan

Contrast enhanced ultrasound using Sonovue microbubble contrast

DIAGNOSTIC_TEST

MRI scan

Arterial-spin labelling magnetic resonance imaging

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Nick Selby · University of Nottingham

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-02
Primary Completion
2025-02-02
Completion
2025-02-02

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06159439 on ClinicalTrials.gov