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Renal MR Feasibility in Renal Disease

NCT03578523 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2018-07-06

No results posted yet for this study

Summary

To use Non-invasive MR Imaging of Renal Physiology and structure to assess patients with Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD).

Conditions

  • Renal Disease

Interventions

OTHER

3 Tesla multiparametric MR

Renal MRI Scan to assess blood flow, perfusion, oxygenation and microstructure (MR T1 relaxation time and diffusion). Each patient will have 3 renal MRI scans.

OTHER

renal histopathology scoring

Blinded fibrosis scoring of renal histopathology (If biopsy performed for clinical indication)

BIOLOGICAL

Blood and urine sampling

Blood and urine sampling around scan sessions; this will include routine patient care biochemistry and haematology panel, urine protein and albumin measurements, stored plasma/serum/urine for subsequent analysis

BIOLOGICAL

Iohexol clearance test

Iohexol clearance to measure GFR within 1 week of the scan session

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Maarten Taal · univeristy of nottingham

  • nick selby · University of Nottingham

Eligibility

Min Age
18 Years
Max Age
95 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-10-31
Primary Completion
2020-12-31
Completion
2020-12-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03578523 on ClinicalTrials.gov