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Validation of Renal Perfusion CEUS Against MRI, and Its Application in Acute Kidney Injury

NCT04181281 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2021-02-17

No results posted yet for this study

Summary

The purposes of this study is 1. To establish the validity of CEUS to measure renal perfusion by comparing it against ASL-MRI in young and older healthy volunteers, and generate a normative dataset of CEUS measures of renal perfusion. 2. Establish proof of principle for the use of CEUS to measure renal perfusion in the acute phase of AKI, demonstrating its feasibility and potential clinical utility. We will do this by performing daily CEUS measurements for up to five days in a cohort of people with AKI stage 3, commencing as close to onset.

of AKI as possible, correlating with clinical data and following outcomes until 90 days.

Conditions

Interventions

DIAGNOSTIC_TEST

Contrast enhanced ultrasound

This is a regular ultrasound scanner used with an ultrasound contrast agent injected through veins to allow for kidney perfusion acquisition.

DIAGNOSTIC_TEST

Arterial Spin Labelling -Magnetic Resonance Imaging

Arterial spin labelling is an MRI technique allow for measuring tissue perfusion. It uses magnetically labelled arterial blood water protons as a tracer.

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Nick Selby · University of Nottingham

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-04-30
Primary Completion
2023-04-30
Completion
2023-04-30

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04181281 on ClinicalTrials.gov