Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury

Summary

Fluid overload is associated with adverse outcomes in patients with severe acute kidney injury. It remains unclear if fluid overload is merely a marker of disease severity or if organ congestion is a mediator of complications. Point-of-care ultrasound could be a modality used to assess organ congestion and its clinical implications. The objective of this study is to determine whether ultrasound markers of organ congestion are associated with major adverse kidney events in critically ill patients with severe acute kidney injury.

Conditions

• Acute Kidney Injury
• Fluid Overload
• Ultrasonography

Interventions

DIAGNOSTIC_TEST

Portal vein flow

Doppler assessment performed on day 0, 3 and 7.

DIAGNOSTIC_TEST

Intra-renal flow

Doppler assessment performed on day 0, 3 and 7.

DIAGNOSTIC_TEST

Hepatic vein flow

Doppler assessment performed on day 0, 3 and 7.

DIAGNOSTIC_TEST

Pulmonary B-lines

Ultrasound assessment of performed on day 0, 3 and 7.

DIAGNOSTIC_TEST

Dimensions of the inferior vena cava

Ultrasound assessment of performed on day 0, 3 and 7.

DIAGNOSTIC_TEST

Left ventricular function

Ultrasound assessment of performed on day 0, 3 and 7.

DIAGNOSTIC_TEST

Right ventricular function

Ultrasound assessment of performed on day 0, 3 and 7.

Sponsors & Collaborators

• Unity Health Toronto

  collaborator OTHER

• Sunnybrook Health Sciences Centre

  collaborator OTHER

• University of Kentucky

  collaborator OTHER

• University of Alberta

  collaborator OTHER

• Montreal Heart Institute

  collaborator OTHER

• Centre hospitalier de l'Université de Montréal (CHUM)

  lead OTHER

Principal Investigators

• William Beaubien-Souligny, MD · CHUM

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-09-04

Primary Completion

2022-01-01

Completion

2022-09-01

Countries

• United States
• Canada

Study Locations