MedTrace Logo

Determination of Factors Involved in the Regulation of Immune Responses After Allogeneic Hematopoietic Stem Cell Transplantation

NCT03357172 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 700

Last updated 2019-10-14

No results posted yet for this study

Summary

The study concerns donors and patients receiving allogeneic stem cell haematopoietic transplantation. The aim of the study is to analyse HSC graft content in immune effector T (naive, memory, activated, exhausted) and immunoregulatory cell subtypes (Tregs, iNKT, MDSC) and correlate the results with post-transplant immune reconstitution of those different cell subtypes and clinical events (graft-versus-host-disease, relapse, infections). An ancillary study will focus on the impact of microbiota dysbiosis on post-transplant immune response and regulatory cell subsets.

Conditions

  • Allogeneic Hematopoietic Stem Cell Transplantation

Interventions

BIOLOGICAL

Blood Sample

Additional blood sample before graft, D0, D7, D15, D21, D30, D60, D90, D180, Y1, Y2

BIOLOGICAL

Bone marrow aspiration

Additional bone marrow aspiration before graft, D30, D90, Y1

BIOLOGICAL

Blood sample

Before donation

BIOLOGICAL

Allogeneic hematopoietic stem cell sample

Allogeneic hematopoietic stem cell sample

Sponsors & Collaborators

  • Central Hospital, Nancy, France

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-10-01
Primary Completion
2026-09-30
Completion
2026-09-30

Countries

  • France

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03357172 on ClinicalTrials.gov