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Comparison of Gut Microbiota, Inflammation and Symptoms Following Allogeneic HSCT

NCT02398708 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 38

Last updated 2019-01-25

No results posted yet for this study

Summary

The purpose of this study is to examine the gut bacteria, levels of peripheral blood inflammation markers, and symptoms in patients with and without chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic stem cell transplant (allo-HSCT). The hypothesis is that individuals with cGVHD will have lower levels of microbial diversity, higher levels of inflammatory metabolites in stool and peripheral measures, and higher levels of symptoms than individuals without cGVHD.

Conditions

  • Graft vs Host Disease
  • Graft Versus Host Disease
  • Hematopoietic Stem Cell Transplantation
  • Peripheral Blood Stem Cell Transplantation

Interventions

OTHER

Questionnaires

Both groups will have questionnaires collected and compared.

OTHER

Blood Sample

Both groups will have a blood sample collected and compared.

OTHER

Stool Sample

Both groups will have a stool sample collected and compared.

OTHER

Clinical data

Both groups will have clinical data collected and compared.

Sponsors & Collaborators

  • American Cancer Society, Inc.

    collaborator OTHER

  • University of Florida

    lead OTHER

Principal Investigators

  • Debra Lynch Kelly, PhD · University of Florida

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-05-31
Primary Completion
2016-04-30
Completion
2016-04-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02398708 on ClinicalTrials.gov