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Changes in the Gut Microbiota of Patients Undergoing Allogeneic Stem Cell Transplantation (COLLECT)

NCT03148197 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2017-07-19

No results posted yet for this study

Summary

COLLECT is a monocentric, prospective, observational study, which aims to assess the association between changes in the intestinal microbiota and the incidence of gastrointestinal graft-versus-host diseases (GvHD). Patients admitted for performance of an allogeneic hematopoietic stem cell transplantation (HSCT) or patients with a first diagnosis of an acute myeloid leukemia (AML) will be enrolled and stool samples will be analyzed using next-generation sequencing. In addition to stool, blood and urine samples will be collected for cytokine and 3-indoxylsulfate analysis.

Exposure to drugs will not be influenced and remains at the discretion of the treating physician.

Conditions

  • Acute Myeloid Leukemia
  • Graft-versus-host-disease
  • Allogeneic Hematopoietic Stem Cell Transplantation
  • Stem Cell Transplant Complications

Sponsors & Collaborators

  • University of Cologne

    lead OTHER

Principal Investigators

  • Maria Vehreschild, MD · University Hospital of Cologne, Department of Internal Medicine / Infectious Diseases, Cologne, Germany

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-07-14
Primary Completion
2019-12-31
Completion
2019-12-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03148197 on ClinicalTrials.gov