The Effect of Obesity Hypoventilation Syndrome on Exercise Capacity, Peripheral Muscle Strength, and Quality of Life in Obese Individuals

Summary

Obesity Hypoventilation Syndrome(OHS) is a disease characterized by daytime hypercapnia and sleep-disordered breathing without other causes of hypoventilation in individuals with a body mass index above 30 kg/m2. Sources state that obesity is at the basis of the metabolic changes seen in individuals with OHS. Obesity, together with cardiovascular system complications, lung volumes, work of breathing and sleep quality, creating the basis for respiratory problems. In addition, sedentary lifestyle habits, which are common in obese individuals, cause negative effects on exercise capacity and peripheral muscle strength. It has been shown in the literature that decreased exercise capacity due to obesity strongly interacts with the risk of all-cause mortality. As a result of obesity and all this negative picture, impaired emotional state and decreased quality of life are observed in individuals. Numerous studies have shown that obese individuals generally have a low level of physical activity, there is a decrease in peripheral muscle strength, obese individuals are at risk for sleep-related respiratory problems and health-related quality of life is often negatively affected in obese individuals. With these studies, the effects of obesity on individuals have been evaluated with objective evaluation methods. However, the same cannot be said for OHS. It is not clear how exercise capacity, peripheral muscle strength and quality of life parameters, which are known to be negatively affected by obesity, are affected in individuals with OHS. Based on this point, this study aims to investigate whether OHS has an additional effect on exercise capacity, peripheral muscle strength and quality of life in addition to obesity.

Conditions

• Obesity Hypoventilation Syndrome
• Obesity
• Hypoventilation
• Respiration Disorders
• Sleep Disorder; Breathing-Related

Interventions

OTHER

Assessment

Between December 2023 and June 204, 46 volunteer participants aged 18 years and older who met the inclusion criteria and were followed up at Istanbul University, Istanbul Faculty of Medicine, Department of Chest Diseases and Istanbul Faculty of Medicine, Department of Internal Medicine were included in the project. Participants' body composition, comorbidities, exercise capacity, peripheral muscle strength, sleep quality and quality of life were assessed.

Sponsors & Collaborators

• Istanbul University - Cerrahpasa

  collaborator OTHER

• Istanbul University

  lead OTHER

Principal Investigators

• Goksen KURAN ASLAN, Assoc. Prof. · Istanbul University - Cerrahpasa

• Ece ACIKBAS, PT,MSc · Istanbul University - Cerrahpasa

• Ozge ERTAN HARPUTLU, PT,MSc · Istanbul University - Cerrahpasa

• Esen KIYAN, Prof · Istanbul University

• Bedia Fulya CALIKOGLU, Lect. PhD · Istanbul University

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-04-10

Primary Completion

2025-01-01

Completion

2025-03-01

Countries

• Turkey (Türkiye)

Study Locations