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Oxygenation Procedure for Obese Patients During Intubation in the Operating Room

NCT06914401 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 124

Last updated 2026-03-06

No results posted yet for this study

Summary

Obesity is a risk factor for difficult intubation, with an incidence of up to 15.5%, and difficult mask ventilation. Obesity also reduces the functional residual capacity (FRC) of the lungs, the main reservoir of oxygen during apnoea. Complications associated with induction and intubation in the operating room are more frequent in obese patients. Preoxygenation is a cornerstone in the management of patients at risk of desaturation during induction. The study aims to compare two oxygenation strategies , in obese patients. Oxygenation using a combination of NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen) compared with NIV alone in the operating room for induction of general anaesthesia with orotracheal intubation.

Conditions

  • Anesthesia Induction

Interventions

PROCEDURE

NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen)

Combination of two procedures Preoxygenation prior to intubation with NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen). During intubation, NIV is stopped and apneic oxygenation is maintained with HFNO

PROCEDURE

NIV (Non Invasive Ventilation)

Single procedure Preoxygenation prior to intubation with NIV (Non Invasive Ventilation).

Sponsors & Collaborators

  • Clinique Pasteur

    lead OTHER

Principal Investigators

  • Ségolène MROZEK, MD, PhD · Clinique Pasteur

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-19
Primary Completion
2027-03-31
Completion
2027-03-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06914401 on ClinicalTrials.gov