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Intrinsic PEEP During Mechanical Ventilation of Patients With Obesity

NCT01267916 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2012-01-31

No results posted yet for this study

Summary

It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEP) is present in grossly obese subjects especially in the supine position. The investigators tried to investigate the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.

Conditions

  • General Anesthesia
  • Laparoscopic Cholecystectomy

Interventions

DEVICE

RR 6 + 0

Respiratory rate 6 Tidal volume 16.7 ml/kg external PEEP = 0

DEVICE

RR 10 + 0

Respiratory rate 10 Tidal volume 10 ml/kg external PEEP = 0

DEVICE

RR 16 + 0

Respiratory rate 16 Tidal volume 6.25 ml/kg external PEEP = 0

DEVICE

RR 6 + 5

Respiratory rate 6 Tidal volume 16.7 ml/kg external PEEP = 5

DEVICE

RR 10 + 5

Respiratory rate 10 Tidal volume 10 ml/kg external PEEP = 5

DEVICE

RR 16 + 5

Respiratory rate 16 Tidal volume 6.25 ml/kg external PEEP = 5

Sponsors & Collaborators

  • Seoul Medical Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-01-31
Primary Completion
2011-12-31
Completion
2011-12-31

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01267916 on ClinicalTrials.gov