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Spinal Cord Gray Matter Imaging in Spinal Muscular Atrophy

NCT06137612 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 52

Last updated 2023-11-18

No results posted yet for this study

Summary

This study aims to measure the spinal cord gray matter in patients with spinal muscular atrophy (SMA) type II and III in comparison with age- and sex-matched healthy controls (HC) using rAMIRA (radially sampled averaged magnetization inversion recovery acquisitions) imaging, a novel MRI (Magnetic Resonance Imaging) method. Patient and HC undergo MRI examinations, clinical/neurological (handheld dynamometry) and electrophysiological investigations (MUNIX, Motor Unit Number Index). Serum markers of neuro-axonal and astrocytic injury are also assessed.

Conditions

  • Spinal Muscular Atrophy Type III
  • Spinal Muscular Atrophy Type II

Interventions

DIAGNOSTIC_TEST

MRI

axial 2D rAMIRA (radially sampled averaged magnetization inversion recovery acquisitions) imaging at selected levels of cervical and thoracic spinal cord at the intervertebral disc levels perpendicular to the spinal cord.

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Eligibility

Min Age
11 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-08-17
Primary Completion
2024-12-31
Completion
2025-09-15

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06137612 on ClinicalTrials.gov