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pH-weighted MRI in Multiple Sclerosis: A Surrogate Marker of Tissue Metabolic Stress

NCT03028675 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 4

Last updated 2020-07-13

No results posted yet for this study

Summary

Twenty subjects (10 patients and 10 age-matched control volunteers) will be recruited for this study. MRI scans will take place on a 3T MRI Scanner (Skyra or Prisma, Siemens Medical Solutions) located at The NYU Center for Biomedical Imaging. MRI scans will consist of a 1-hour brain scan for both patients and controls. In the first 6 months of the study, investigators will develop and test a uMT-based APT imaging for brain tissue pH measurement and use a hypercapnia paradigm to validate the tissue pH changes between breathing room air and 5% CO2 (by increasing tissue acidity) inhalation. With implementation of hypercapnia MRI, pH-weighted imaging will be validated for its robustness and reproducibility.

Conditions

Interventions

OTHER

MRI Scan

MRI scans will consist of a 1-hour brain scan for both patients and controls.

Sponsors & Collaborators

Principal Investigators

  • Yulin Ge, MD · New York University Medical School

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-05-01
Primary Completion
2018-08-10
Completion
2018-08-10

Countries

  • United States

Study Locations

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Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03028675 on ClinicalTrials.gov