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Mechanisms of Fasting Induced Reduction in Energy Expenditure

NCT06134258 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2025-05-30

No results posted yet for this study

Summary

Fasting reduces the energy consumption of the human body. The extent of this adaptation varies significantly between different individuals. The aim of this research project is to investigate how this adaptation of the metabolism is regulated by the body. For this purpose, we will first measure how the so-called basal metabolic rate of the body reacts to a short-term fasting of 24 h in a preliminary study. Those subjects with a particularly pronounced and those subjects with an only slightly pronounced reaction of the basal metabolic rate will be invited to the main study.

Here, in random order (24 h fasting vs. 8 h fasting), the following is compared

* how the basal metabolic rate of the body reacts to the reduced energy intake.
* how the energy metabolism increases after a test meal
* what role in particular the thyroid hormones play in this adaptation. In addition, a sample of the subcutaneous adipose tissue is taken in each case and it is examined how the regulation of metabolic processes at the cellular level.

Conditions

  • Fasting

Interventions

OTHER

mixed meal test

mixed meal test after fasting

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    collaborator OTHER

  • ETH Zurich

    lead OTHER

Principal Investigators

  • Matthias Betz · University Hospital, Basel, Switzerland

  • Christian Wolfrum · ETH Zurich

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-11-15
Primary Completion
2026-04-18
Completion
2026-04-18

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06134258 on ClinicalTrials.gov