Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps
NCT06129552 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300
Last updated 2024-03-22
Summary
During this project, the investigators want to explore in vitro changes in basal cells and the crosstalk with residing immune cells as potential pathogenic mechanisms in CRSwNP vs healthy controls by using surgically resected patient samples.
Conditions
- Chronic Rhinosinusitis With Nasal Polyps
- Allergic Rhinitis
Interventions
- PROCEDURE
-
Conchotomy, aesthetic nose surgery or functional endoscopic sinus operation
Conchotomy involves the reduction or removal of hypertrophic nasal turbinates, aesthetic nose surgery is a surgical procedure that aims to enhance the appearance of the nose, while functional endoscopic sinus surgery is a minimally invasive procedure focused on treating sinus conditions by removing obstructions and improving sinus drainage.
Sponsors & Collaborators
- collaborator INDUSTRY
-
Universitaire Ziekenhuizen KU Leuven
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2023-12-19
- Primary Completion
- 2027-10-31
- Completion
- 2027-12-31
Countries
- Belgium
Study Locations
More Related Trials
-
Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
NCT06776042 ·Status: RECRUITING ·Phase: NA
-
BIOlogics in Severe Nasal POlyposis SurvEy.: a French Registry
NCT06501807 ·Status: RECRUITING ·Phase: NA
-
EValuating trEatment RESponses of Dupilumab Versus Omalizumab in Type 2 Patients
NCT04998604 ·Status: COMPLETED ·Phase: PHASE4
-
Dupilumab Treatment Effects in an Ethnically Diverse Population With Chronic Rhinosinusitis With Nasal Polyposis
NCT05246267 ·Status: RECRUITING
-
Mepolizumab in the Treatment of Patients With Severe Uncontrolled CRSwNP: a Multicentric Real Life Observational Study
NCT06258772 ·Status: NOT_YET_RECRUITING
-
Biologics in Chronic Rhinosinusitis With Nasal Polyposis
NCT06824649 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
Treatment of Allergic Rhinitis and Chronic Polypous Rhinosinusitis With Olfactory Mucosa-derived Mesenchymal Stem Cells
NCT05167552 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Prospective Single-center Cohort Study of Surgical Treatment of Chronic Rhinosinusitis
NCT06010316 ·Status: RECRUITING
-
Comparison of Immune Profiles in Chronic Rhinosinusitis Patients After Mepolizumab Treatment
NCT05642806 ·Status: RECRUITING ·Phase: PHASE4
-
Identifying Predictors Of Response To Mepolizumab In CRSwNP
NCT05902325 ·Status: RECRUITING ·Phase: PHASE4
-
The Role of IL5 in Epithelial Cell Integrity
NCT05895929 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Predictive Factors in Chronic Rhinosinusitis With Nasal Polyps
NCT06459622 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP
NCT05672030 ·Status: COMPLETED
-
Subcutaneous Omalizumab for Treatment of Chronic Rhinosinusitis With Nasal Polyposis
NCT01066104 ·Status: COMPLETED ·Phase: PHASE2
-
th2 Modulation CRSwNP
NCT06107101 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
Tissue Immune Interaction in Nasal Polyposis
NCT04628442 ·Status: COMPLETED
-
Effect of Dupilumab on Sleep Apnea in Patients With Rhinosinusitis
NCT03675022 ·Status: TERMINATED ·Phase: EARLY_PHASE1
-
Mepolizumab Effectiveness in Patients With Chronic Rhinosinusitis, Nasal Polyps and Comorbid Severe Eosinophilic Asthma
NCT06069310 ·Status: ACTIVE_NOT_RECRUITING
-
Study in Adults With Severe Chronic Rhinosinusitis With Nasal Polyposis Treated With Dupilumab in France
NCT06393946 ·Status: ACTIVE_NOT_RECRUITING
-
Correlation Between the Microbiome and Type 2 Inflammatory Diseases of CRSwNP
NCT06231004 ·Status: NOT_YET_RECRUITING
-
Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
NCT03122795 ·Status: COMPLETED ·Phase: NA
-
Comparison of Two Steroid Nasal Implants Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis
NCT03729310 ·Status: WITHDRAWN ·Phase: EARLY_PHASE1
-
Qualitative Analysis of Subject Experience of Nasal Polyps
NCT03221192 ·Status: COMPLETED
-
A Study to Evaluate 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps
NCT06639295 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Study of CM326 in Participants With Chronic Rhinosinusitis With Nasal Polyposis
NCT06372678 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2