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Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP

NCT05672030 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2025-11-24

Study results available
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Summary

The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant effector pathways that lead to clinical benefit.

Conditions

  • Nasal Polyps
  • Aspirin-exacerbated Respiratory Disease

Interventions

OTHER

Non-Interventional

No intervention.

Sponsors & Collaborators

  • Brigham and Women's Hospital

    lead OTHER

Principal Investigators

  • Tanya Laidlaw · Brigham and Women's Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-10-01
Primary Completion
2023-12-01
Completion
2023-12-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05672030 on ClinicalTrials.gov