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Assessing the Performance of Shotgun Metagenomics in the Diagnosis of Complex Prosthetic Joint Infections

NCT06062251 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 143

Last updated 2025-02-05

No results posted yet for this study

Summary

The objectiveof this of a prospective, multicentre study is to evaluate the performance of shotgun metagenomics in the diagnosis of chronic Prosthetic joint infection (PJI) in comparison with the adapted MSIS diagnostic score..

The main questions it aims to answer are:

* To evaluate the performance of shotgun metagenomics in the diagnosis of chronic PJI in comparison with culture.
* To describe the epidemiology of bacterial species responsible for chronic PJI in Western France and their potential resistance to antibiotics.
* Analyzing the diagnostic performance of shotgun culture and metagenomics as a function of potentially administered antibiotic treatments A total of 143 patients sampled will be included. Six intraoperative samples will be taken for each patient, as part of routine care. In addition to the standard preoperative check-up, an extra volume of blood will be taken for CRP measurement at inclusion.

Conditions

  • Prosthetic Joint Infection

Sponsors & Collaborators

  • University Hospital, Brest

    lead OTHER

Principal Investigators

  • Rachel CHENOUARD, Dr · Angers HU

  • Stéphane CORVEC, PhD · Nantes HU

  • Chloé PLOUZEAU, Dr · Poitier HU

  • Sophie REISSIER, Dr · Rennes HU

  • Marie-Frédérique LARTIGUE, Dr · Tours HU

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-02-27
Primary Completion
2025-09-30
Completion
2026-06-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06062251 on ClinicalTrials.gov