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Gut Microbiome of Patients Undergoing Antibiotic Therapy for Orthopedic Device-related Infection

NCT04440631 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 12

Last updated 2023-02-03

No results posted yet for this study

Summary

The microbiome of 80 orthopedic-device related infection (ODRI) patients treated with antibiotics and 10 healthy controls will be investigated. Samples (blood, stool, saliva, skin-swab) are collected 4x within 6 months. Composition and diversity of the microbiome will be assessed by 16sRNA sequencing, skins swabs are screened for rifampicin-resistant staphylococci onto Mannitol-salt-agar plates supplemented with rifampicin, inflammation markers and antibodies in blood and saliva are monitored to track changes in the immune response. For further analysis patients are assigned to one of two groups: 1) antibiotic therapy including rifampicin and 2) non-rifampicin antibiotic therapy.

Conditions

  • Fractures, Bone
  • Infection, Bacterial
  • Joint Infection
  • Bone Infection

Interventions

OTHER

no intervention, observational only

no intervention, observational only

Sponsors & Collaborators

  • AO Research Institute Davos

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-11-01
Primary Completion
2022-06-01
Completion
2022-12-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04440631 on ClinicalTrials.gov