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Clinical Metagenomic of Post-traumatic Infections

NCT05770856 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2024-07-29

No results posted yet for this study

Summary

Treatment of fracture related infection is challenging and often lead to failure in such situation that carry a high health cost burden.

These infections are often polymicrobial, making the identification of all involved microorganisms a major concern to provide tailored antibiotic treatment. Culture-independent methods are needed to better represent the microbial diversity of infected wounds. Metagenomic sequencing might lead to an accurate microbiome characterization in infected trauma-related wound.

Preliminary studies have reported results of metagenomic sequencing in diabetic foot infection but data focusing on non-diabetic infected patients are scarce.

The impact of post-traumatic infected wound microbiome needs to be assessed, with regards to bacterial abundance, diversity including at the strain level and functional genes, along with their longitudinal evolution and association with clinical outcomes.

Conditions

Interventions

DIAGNOSTIC_TEST

Metagenomic sequencing

Samples shall be submitted to high throughput sequencing using both illumine MiSeq and Oxford Nanopore Technologies.

Sponsors & Collaborators

  • Military Teaching Hospital Sainte Anne, Toulon

    collaborator UNKNOWN

  • UMR Vitrome, IRD 257

    collaborator UNKNOWN

  • Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

    lead OTHER

Principal Investigators

  • David LACÔTE-DELARBRE, MD · Military Teaching Hospital Sainte Anne

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-27
Primary Completion
2023-07-15
Completion
2023-07-15

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05770856 on ClinicalTrials.gov