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INtestinal Dysbiosis and TRanslocation of Bacteria in Patients Undergoing Surgery

NCT05775341 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2026-04-29

No results posted yet for this study

Summary

The goal of this observational study is to contribute to a better understanding of the perioperative kinetics of intestinal microbial composition and association with surgical site infections.

The main question this study aims to determine if:

* Patients undergoing surgery develop transient intestinal dysbiosis
* Such transient dysbiosis is associated with translocation to the systemic circulation and surgical site infection

Patients undergoing elective abdominal surgery will be included prospectively. Informed consent will be obtained. From patients the following information and samples will be collected:

* Perioperative: Baseline health data, nutrition data, measurement body composition, glucose monitoring
* Intraoperatively:

* Mucosal swabs
* Blood from central venous catheter and portal vein
* Mesenteric lymph node
* Intestinal specimen
* Bile
* Subcutaneous biopsy
* Postoperatively:

* If a surgical site infection occurs samples from infected site

Conditions

  • Surgical Site Infection

Interventions

OTHER

No Intervention

This is purely an observational study.

Sponsors & Collaborators

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Guido Beldi · Department of Visceral Surgery and Medicine, Bern University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-02-27
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05775341 on ClinicalTrials.gov