MedTrace Logo

Nitrate Modulates Cognitive Impairment Via Oral Microbiota.

NCT05963659 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2025-06-03

No results posted yet for this study

Summary

Alcohol use is increasingly prevalent in modern society and is known to cause cognitive impairment and dysregulation of inflammatory responses. In the present study, the investigators want to perform a randomised controlled trials to test whether nitrate could change the oral microbiota and benefit the cognitive impairment in alcohol dependence patients. The investigators survey the oral bacterial communities in saliva samples of 70 alcohol dependent patients following 14 days of dietary inorganic nitrate (nitrate-rich beetroot juice, \~750 mg NO3- /d) and placebo (nitrate-depleted beetroot juice, \~1 mg NO3- /d) supplementation.

Conditions

  • Microtia
  • Alcohol Dependence

Interventions

DIETARY_SUPPLEMENT

nitrate-rich beetroot juice

nitrate-rich beetroot juice, \~750 mg NO3- /d

DIETARY_SUPPLEMENT

nitrate-depleted beetroot juice

nitrate-depleted beetroot juice, \~1 mg NO3- /d

Sponsors & Collaborators

  • Peking University Sixth Hospital

    lead OTHER

Principal Investigators

  • Hongqiang Sun · Peking University Sixth Hospital

  • Liangjun Pang · Anhui mental health central

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-09-10
Primary Completion
2024-08-07
Completion
2024-08-07

Countries

  • China

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05963659 on ClinicalTrials.gov