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FIT to Grow Old - Functionality of the Immune System and Healthy Aging

NCT05940337 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 156

Last updated 2024-01-22

No results posted yet for this study

Summary

Aging is commonly associated with reduced functionality of the immune system, resulting in a higher prevalence of infectious disease, auto-immune disease, cancer, and lower efficiency of vaccination. Nutritional strategies are increasingly recognized as a method to improve immune functionality, as several nutrients are shown to exert immunomodulatory properties. However, the large variation between individuals with regard to immune responses asks for more personalized approaches. Therefore, this field of research would benefit from a selection of those individuals with immune dysfunction. It is recently shown that immune functionality is largely dependent on intracellular metabolism, leading to the introduction of the new term 'immune cell fitness' which combines the metabolic and functional status of an immune cell. Within this study, we will determine the immune cell fitness of monocytes from healthy young adults and elderly subjects by measuring and integrating a broad range of metabolic and functional immune parameters into an immune cell fitness score. We aim to identify those individuals with immune dysfunction, the unfit. Furthermore, to identify potential nutritional strategies to improve immune cell fitness, we will study the effects of metabolites and nutrients on the immune cell fitness status of monocytes from elderly subjects.

Conditions

  • Aging

Sponsors & Collaborators

  • Top Consortium for Knowledge and Innovation (TKI) Argi & Food

    collaborator UNKNOWN

  • Mead Johnson Nutrition

    collaborator INDUSTRY

  • Hycult Biotech

    collaborator UNKNOWN

  • Wageningen University

    lead OTHER

Principal Investigators

  • Lydia Afman · Wageningen University

  • Rinke Stienstra · Wageningen University

Eligibility

Min Age
20 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-11
Primary Completion
2023-07-31
Completion
2023-07-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05940337 on ClinicalTrials.gov