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Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status

NCT06009276 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 70

Last updated 2025-12-24

No results posted yet for this study

Summary

The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to send blood to the skeletal muscle.

Participants will complete all or some of the following:

* A mouth swab to assess the bacteria in their mouths.
* Produce a saliva sample into a tube.
* Cycle on a bike until you reach maximum effort.
* Undergo blood draws
* Wear a 24-hour non-invasive device that monitors blood pressure.
* Drink 70mL (1/3 of a cup) of concentrated beetroot juice once

Conditions

  • Heart Failure, Systolic
  • Heart Failure, Diastolic
  • Peripheral Arterial Disease
  • Overweight and Obesity

Sponsors & Collaborators

  • University of Virginia

    lead OTHER

Principal Investigators

  • Jason D Allen, PhD · University of Virginia

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-08-30
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06009276 on ClinicalTrials.gov