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Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3

NCT05275751 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 51

Last updated 2023-03-17

No results posted yet for this study

Summary

Animal studies suggest that the ion channels TRPV1, TRPA1 and TRPM3 are the relevant heat sensors. This study aims to validate these findings in humans.

Conditions

Interventions

DRUG

TRPA1-inhibitor

Pharmacological inhibition of TRPA1 during intradermal injection of hot synthetic interstitial fluid

DRUG

TRPV1-inhibitor

Pharmacological inhibition of TRPV1 during intradermal injection of hot synthetic interstitial fluid

DRUG

TRPM3-inhibitor

Pharmacological inhibition of TRPM3 during intradermal injection of hot synthetic interstitial fluid

DRUG

Placebo

No pharmacological intervention

DRUG

Chloride-channel inhibitor

Pharmacological inhibition of a chloride channel during intradermal injection of hot synthetic interstitial fluid

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Michael JM Fischer, Professor MD · Medical University of Vienna

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-06-13
Primary Completion
2022-11-30
Completion
2022-11-30

Countries

  • Austria

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05275751 on ClinicalTrials.gov