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Clinical and Histological Analysis of Human Gingival Phenotypes

NCT05923671 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2023-06-28

No results posted yet for this study

Summary

The goal of this observational study is to compare the composition of the human gingiva in different gingival phenotypes. The main questions to answer are:

* Is there any difference in the cellular composition of the gingiva between thin and thick gingival phenotype?
* Is there any difference in the molecular composition of the gingiva between thin and thick gingival phenotype?

The participants were divided in two groups (thin and thick phenotype) and a biopsy of healthy gingiva was obtained from each one them. The biopsies were analyzed histologically and the collected data will be analyzed statistically in order to identify possible differences between the gingival phenotypes.

Conditions

  • Healthy

Interventions

DIAGNOSTIC_TEST

Histological analysis

Histological staining of gingival biopsies with haematoxylin-eosin.

DIAGNOSTIC_TEST

Immunohistochemical analysis

Immunohistochemical staining of gingival biopsies using anti-Vimentin, anti-Collagen I, anti-Collagen V, anti-Elastin, anti-Hyaluronic acid, anti-Smooth muscle actin, anti-Cluster of Differentiation 68 and anti-ki67 antibodies.

Sponsors & Collaborators

  • Umeå University

    collaborator OTHER

  • Aristotle University Of Thessaloniki

    lead OTHER

Principal Investigators

  • Sotiris Kalfas, Professor · Aristotle University Of Thessaloniki

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-03-05
Primary Completion
2022-12-01
Completion
2022-12-01

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05923671 on ClinicalTrials.gov